Posted by: Dan | October 1, 2007

DISC1, Schizophrenia, and Neurogenesis


I’d be remiss for not mentioning the recent paper on disrupted-in-schizophrenia 1 (DISC1) and adult neurogenesis in Cell. DISC1 was originally identified as a schizophrenia-susceptibility gene, with early work on its role in development. Not much is really known about it yet, but Duan et al. found that DISC1 downregulation led to accelerated neuronal integration, resulting in aberrant morphological development and mispositioning of new dentate granule cells in the adult CNS.

However DISC1 is influencing neurogenesis, a whole lot of neuronal migration is goin’ on.

  • Dranovsky A, Hen R. DISC1 Puts the Brakes on Neurogenesis.
    Cell. 2007 Sep 21;130(6):981-3.
  • Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain.
    Cell. 2007 Sep 21;130(6):1146-1158.


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