This month’s Nature Reviews Molecular Cell Biology has a review worth mentioning in brief: The Complexity of Adhesion. Ekat Kritikou attempts to put an NCB paper on the Functional Atlas of the Integrin Adhesome (illustrated above) into its proper context. Sorry, subscriptions required.
As the Zaidel-Bar et al. point out “…these findings can stimulate modelling and simulations that will further our understanding of how adhesion sites are formed and regulated, and how these molecular machines are capable of sensing the chemical and physical properties of their environment.”
… making complexity more accessible.
- Kritikou, E. The complexity of adhesion. Nat Rev Mol Cell Biol 8:674 (2007). doi:10.1038/ncb0807-858
- Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol 9:858-867 (2007). doi:10.1038/ncb0807-858