In inflammation, leukocytes are recruited to specific regions of the body, and to get there, those leukocytes need to cross barriers, membranes, and stroma in tissues. The blood-brain barrier (BBB) is the big cheese amongst such obstacles, and protects the central nervous system (CNS) from elements normally in the circulatory system, such that inflammation in the CNS is unique from that in peripheral tissues. A review in the journal Brain Pathology takes a look at how leukocytes cross the BBB, and the implications for treatment of pathologies like Multiple Schlerosis. Adhesion molecules and chemokine receptors play critical roles in leukocyte migration, and therefore are attractive drug targets in such treatments.
- Man S, Ubogu EE, Ransohoff RM. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol. 2007 Apr;17(2):243-50. Pubmed